Editing TINF2 as a Potential Therapeutic Approach to Restore Telomere Length in Dyskeratosis Congenita
Despite their frequency and severe impact on children in the TBD community, mutations in the gene TINF2 remain some of the least understood causes of telomere biology disorders (TBDs). Significantly, one central question related to how these mutations cause disease...
Characterization of Telomere Maintenance in Tumor Models of Dyskeratosis Congenita
by Dr. Judy Wong
Our amazing 2020 Team Telomere Million Dollar Bike Ride Grant Awardee was Dr. Judy Wong! Her project, “Characterization of Telomere Maintenance in Tumor Models of Dyskeratosis Congenita”, worked to understand how cancer develops in individuals with Telomere Biology...
Studying the Functional Interaction Between Compound Heterozygous TERT Mutations
by Dr. Tracy Bryan
My laboratory first started work on telomerase, the molecule that elongates telomeres, more than 20 years ago; at the time, we were interested in the fundamental biochemistry behind this intriguing molecule, and how we might target it for cancer therapy. This...
Disease Progression and Clinical Outcomes in Telomere Biology Disorders
by Dr. Marena Niewisch and Dr. Sharon Savage
Individuals with telomere biology disorders (TBDs) like dyskeratosis congenita (DC) are confronted with numerous health issues during their lifetime. TBDs do not always look the same – some people may have symptoms very early in life while others develop their first...
